What is normal mannose binding lectin?
Normal serum levels of MBL range from 800 to 1000 ng/ml in healthy Caucasians, however, wide variations can occur due to point mutations in codons 52, 54 and 57 of exon 1 and/or in the promotor region of the MBL gene [3].
What is the main function of MBL?
Binding of MBL to a micro-organism results in activation of the lectin pathway of the complement system. Another important function of MBL is that this molecule binds senescent and apoptotic cells and enhances engulfment of whole, intact apoptotic cells, as well as cell debris by phagocytes.
What does high mannose binding lectin mean?
A role for mannose binding lectin (MBL) in autoimmune diseases has been demonstrated earlier and elevated level of MBL has been shown in systemic lupus erythematosus (SLE) patients. In the current study, we investigated MBL as a potential biomarker for disease activity in SLE.
What does mannose binding lectin recognize?
MBL recognizes specific carbohydrates such as d-mannose, l-fucose and N-acetylglucosamine that are represented on the surface of a wide variety of infectious agents (Figure 1b) [1]. Pathogens targeted by MBL include certain Gram-positive and Gram-negative bacteria, yeast, parasites and viruses [9].
How is mannose-binding lectin deficiency treated?
Treatment for individuals with recurrent infections and MBL deficiency may include antibiotics to treat bacterial infections and regular vaccinations. Prophylactic antibiotics may be indicated in some cases.
Is mannose-binding lectin an acute phase protein?
Mannose-binding lectin (MBL) is an acute-phase protein that can opsonize many bacterial and fungal pathogens and activate complement (Kuhlman et al., 1989).
How is mannose binding lectin formed?
MBL is formed by 3–6 oligomers of trimeric subunits, Ficolins form homooligomers of 4–6 trimeric subunits, and CL-LK is a heteromeric complex between CL-L1 and CL-K1 [reviewed in Cedzyński et al. (2018), Matsushita (2018), and Ohtani and Wakamiya (2018)].
Is mannose binding lectin a complement?
The lectin pathway is one of three pathways by which the complement system can be activated. This pathway is initiated by the binding of mannose-binding lectin (MBL), collectin 11 (CL-K1), and ficolins (Ficolin-1, Ficolin-2, and Ficolin-3) to microbial surface oligosaccharides and acetylated residues, respectively.
How is mannose binding lectin deficiency treated?
Is MBL deficiency an autoimmune disease?
Mannose binding lectin (MBL) deficiency may be associated with increased susceptibility to infection and autoimmune disorders, such as systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA).
What is the function of mannose binding protein?
Mannose-binding lectin plays an important role in the body’s immune response by attaching to foreign invaders such as bacteria, viruses, or yeast and turning on (activating) the complement system .
