What is the Periarterial lymphatic sheath?
Periarteriolar lymphoid sheaths (or periarterial lymphatic sheaths, or PALS) are a portion of the white pulp of the spleen. They are populated largely by T cells and surround central arteries within the spleen; the PALS T-cells are presented with blood borne antigens via myeloid dendritic cells.
What organ is missing from the rat that we find in a human?
The spleen of mice and rats exhibits an additional well-delineated B-cell compartment, the marginal zone, between white and red pulp. This area is, however, absent in human spleen.
How do you check for spleen histology?
The spleen is comprised of red pulp and white pulp. The red pulp is the site of blood filtration and the white pulp is lymphoid tissue that responds to blood-borne antigens. Identify under low power some of the structures that are diagnostic of the organ.
Where is the spleen located in a rat?
The spleen is a dark red to blue-black organ located in the left cranial abdomen. It is adjacent to the greater curvature of the stomach and within the omentum.
What is the function of white pulp of the spleen?
White pulp consists entirely of lymphoid tissue. Specifically, the white pulp encompasses several areas with distinct functions: The periarteriolar lymphoid sheaths (PALS) are typically associated with the arteriole supply of the spleen; they contain T lymphocytes….
| White pulp | |
|---|---|
| TA2 | 5176 |
| Anatomical terminology |
What is white pulp in spleen?
The white pulp is the lymphatic tissue of the spleen, organized into cylinders supplied by a central artery.
Which organ lies under the stomach and secretes insulin?
The pancreas
The pancreas is a brownish, flattened gland found in the tissue between the stomach and small intestine. The pancreas produces digestive enzymes that are sent to the intestine via small ducts (the pancreatic duct). The pancreas also secretes insulin, which is important in the regulation of glucose metabolism.
Why do we dissect rats?
A rat dissection is conducted to explore the internal structure and function of basic mammalian anatomy. The purpose of this exercise is to explore the alimentary canal of the rat and observe the different parts of the digestive system.
What does the trabeculae in the spleen do?
The spleen is covered by a dense capsule, and there are connective tissue trabeculae, which provide internal support for the spleen, and carry the blood vessels into the spleen.
Does the spleen have macrophages?
We have characterized the major resident macrophages in the human spleen, the red pulp macrophages, as a unique population with major differences in expression for surface receptors such as the FcγRs, as opposed to monocytes and monocyte-derived macrophages.
What does rat spleen do?
The basic function of the spleen in the rat, similarly as in man, is to cleanse the blood of damaged old particles of the body itself, but also of foreign particles. To fulfill this function, the spleen is equipped with the white and red pulp with a specific structure of blood circulation.
What lies under the stomach and secretes insulin?
The pancreas is a brownish, flattened gland found in the tissue between the stomach and small intestine. The pancreas produces digestive enzymes that are sent to the intestine via small ducts (the pancreatic duct). The pancreas also secretes insulin which is important in the regulation of glucose metabolism.
